pathway

Nlrp3 Inflammasome

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Nlrp3 Inflammasome: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

874Connections

1Hypotheses

1Analyses

33Outgoing

50Incoming

No summary available yet. View on Wiki →

🔀 Pathway Info

Name	Nlrp3 Inflammasome
Key Genes/Proteins	ZFP36, USP9X, HDAC3, TLR2, IL1B
Related Diseases	Parkinson'S Disease, Inflammatory Diseases, Neurodegeneration
Related Pathways	Usp9X Suppression, Tlr2 Inhibition, Caspase-1 Activation
Linked Hypotheses	3 hypotheses

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    NLRP3["NLRP3"] -->|"activates"| Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    HIF1A["HIF1A"] -->|"activates"| Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    APOPTOSIS["APOPTOSIS"] -->|"activates"| Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    AND["AND"] -->|"activates"| Nlrp3_Inflammasome["Nlrp3 Inflammasome"]
    style Nlrp3_Inflammasome fill:#1b5e20,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (313)

Target	Relation	Type	Str
Pyroptosis	mediates	process	0.95
Caspase-1 Activation	activates	mechanism	0.93
IL1B	upregulates	gene	0.92
Neuroinflammation	activates	process	0.90
Neuroinflammation	mediates	process	0.90
Parkinson'S Disease	involved_in	disease	0.90
Inflammatory Diseases	involved_in	disease	0.90
Neurodegeneration	contributes_to	phenotype	0.88
Placental Trophoblast Dysfunction	mediates	process	0.85
Inflammatory Cytokine Expression	upregulates	process	0.85
IL1B	activates	gene	0.85
CASP1	activates	gene	0.85
IL-1	activates	concept	0.50
CYTOKINE	activates	concept	0.50
GASDERMIN	regulates	gene	0.50
Proteins	regulates	protein	0.50
TEMPORAL LOBE	regulates	concept	0.50
Proteins	expressed_in	protein	0.50
cGAS-STING pathway	activates	pathway	0.50
Neuroprotection	activates	process	0.50
METFORMIN	activates	concept	0.50
GASDERMIN	associated_with	gene	0.50
ISCHEMIC STROKE	activates	concept	0.50
SYNUCLEIN	activates	concept	0.50
α-SYNUCLEIN	activates	concept	0.50
CENTRAL NERVOUS SYSTEM	associated_with	concept	0.50
DOPAMINE	activates	concept	0.50
ENDOPLASMIC RETICULUM	activates	concept	0.50
AUTOPHAGOSOME	activates	concept	0.50
SELECTIVE AUTOPHAGY	activates	concept	0.50
CEREBRAL CORTEX	activates	concept	0.50
IL-1	regulates	concept	0.50
DOPAMINE	regulates	concept	0.50

Incoming (561)

Source	Relation	Type	Str
ZFP36	inhibits	gene	0.95
USP9X	regulates	gene	0.95
Usp9X Suppression	inhibits	mechanism	0.95
HDAC3	promotes	gene	0.95
GS-1	suppresses	compound	0.95
TLR2	activates	gene	0.95
Tlr2 Inhibition	suppresses	mechanism	0.95
Biomechanical Strain	activates	process	0.88
Mitochondrial Damage	activates	process	0.88
Microglia	associated_with	cell_type	0.85
PARKIN	regulates	gene	0.85
Vitamin D	suppresses	compound	0.80
PYCARD	involved_in	protein	0.80
Ubiquitination	regulates	process	0.80
NLRP3	activates	gene	0.60
HIF1A	activates	gene	0.60
APOPTOSIS	activates	gene	0.60
AND	activates	gene	0.60
MITOPHAGY	activates	gene	0.60
BNIP3	activates	gene	0.60
NLRP3	interacts_with	gene	0.60
AND	associated_with	gene	0.60
ALZHEIMER DISEASE	interacts_with	gene	0.60
PYROPTOSIS	activates	gene	0.60
APOPTOSIS	interacts_with	gene	0.60
ALZHEIMER	interacts_with	gene	0.60
NEK7	activates	gene	0.60
NLRC4	activates	gene	0.60
AMYLOID	activates	gene	0.60
ATP	activates	gene	0.60
ASC	activates	gene	0.60
NLRP3	regulates	gene	0.60
AND	regulates	gene	0.60
ZDHHC12	activates	gene	0.60
NLRP3	associated_with	gene	0.60
GAIN	inhibits	gene	0.60
INFLAMMATION	inhibits	gene	0.60
AIM2	inhibits	gene	0.60
NLRP3	inhibits	gene	0.60
AMPK	inhibits	gene	0.60
AND	inhibits	gene	0.60
EXERCISE	inhibits	gene	0.60
AUTOPHAGY	inhibits	gene	0.60
NLRC4	inhibits	gene	0.60
SIRT2	inhibits	gene	0.60
Β-HYDROXYBUTYRATE	inhibits	gene	0.60
ROS	inhibits	gene	0.60
UCP2	inhibits	gene	0.60
ASC	inhibits	gene	0.60
PARKINSON'S DISEASE	therapeutic_target	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Astrocyte-Intrinsic NLRP3 Inflammasome Activation by Alpha-S	0.599	neurodegeneration	What are the mechanisms by which gut mic

Mentioning Analyses (1)

Scientific analyses that reference this entity

Lysosomal dysfunction and cathepsin leakage in Alzheimer disease progression

neuroscience | 2026-04-04 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Nlrp3 Inflammasome

Understanding Entity Pages

Wiki Pages (20)

cbs-psp-daily-action-plan

Corticobasal Syndrome (CBS)

Novel Therapy Index

CBS/PSP Supplements Guide

Atypical Parkinsonism

calcium-dysregulation-comparison

Alpha-Synuclein Pathology

Alzheimer's Disease Mechanism Index

Therapeutics

neuroinflammation

Alzheimer's Disease

Microglial Cells — Cell Type Hierarchy

NTF4 Protein

TREM2 Mechanism Hub

Neuroimmune Response in 4R-Tauopathies: Cross-Disease Comparison

GSK-3β in Neurodegeneration

Mitochondrial Dysfunction in Parkinson's Disease

Autophagy Mechanisms

APOC4 — Apolipoprotein C-IV